Joc Pederson is hitting leadoff for the first time in his major-league career against the San Francisco Giants. (Getty Images)

Don Mattingly‘s lineup card for Wednesday’s game against the San Francisco Giants is more radically different than perhaps any this season.

Joc Pederson bats first for the first time. Jimmy Rollins bats second for the first time. Howie Kendrick is third, Adrian Gonzalez fourth and Yasmani Grandal seventh — all for the first time in 2015.

“Carl’s (injury) was the biggest” factor for changing the lineup, Mattingly said. “I think as we’ve watched Joc kind of, you know, keep growing, you want to get him in the mix, as far as getting more at-bats.”

Carl Crawford strained his right oblique muscle on Tuesday and is on the 15-day disabled list. Pederson is slashing .296/.458/.556 having batted no higher than seventh this season. His 16 walks are tied for second in the National League and his .458 batting average ranks third.

Some of that, of course, is a function of Pederson’s knowledge of the strike zone. Part of that is batting in front of the pitcher most nights.

To some extent, Mattingly wants to “take the kid gloves off” the 23-year-old rookie.

“When you’re sitting back in the seven/eight hole, if you’re not hitting at all, you’re (not) really killing the club,” Mattingly said. “It was a good place for him to start and he may end up back there. We haven’t made any promises. We don’t know what happens when Yasiel (Puig) comes back. Things like that. But for now we think with our group of guys he fits right there.”

Grandal moves to the seventh spot in the batting order at a time when he is slashing .196/.317/.294. Here’s what Mattingly said about Grandal prior to Wednesday night’s game: