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Now to the East, where the youngest team in the tournament is the region's No. 1 seed.

Overall theme: Well-renowned coaches looking to get over "the hump"
The coaches of the top two seeds, Kentucky's John Calipari and West Virginia's Bob Huggins, are two of the more respected coaches in the game. They've combined to win 1,090 games and have combined for three Final Four appearances. However, neither coach has won a national title and only one (Calipari) has even been in the championship game. This year could either boost their legacies or cement them as guys who couldn't quite win the big one. Wisconsin's Bo Ryan, who has never been to a Final Four, is in a similar boat as well.

Watch out for: No. 2 West Virginia
While Huggins' teams have underachieved in the tournament in the past - last year's first-round flameout being the latest - the stars seem aligned for a long Mountaineer run this year. They are the No. 2 seed in a region where the No. 1 seed (Kentucky) has star players barely able to vote and a No. 3 seed (New Mexico) that plays in a mid-major conference. The Mountaineers have length, size, and athleticism in the forward and wing guard spots and can play a variety of styles. There's no reason for WVU not to at least make the Elite 8.

Stay away from: No. 12 Cornell
This seems kind of a copout, but the chic "12-over-5" upset pick has involved the Big Red beating No. 5 Temple. I get a bit wary when everyone jumps on an upset pick - makes me think twice about its validity. Cornell is getting its props for almost beating Kansas in December but it couldn't make it through the Ivy League unscathed, losing to conference doormat Penn at one point. Temple has 29 wins in an underrated Atlantic 10 and has plenty of athleticism on the perimeter. Don't see the Ivy League kids winning this one.

High risk, high reward: The Washington-Marquette winner
Another kind of goofy pick, but the winner of the 11-6 matchup between the Huskies and the Golden Eagles are set up for a run into the second weekend. Marquette is guard heavy with an elite scorer in forward Lazar Hayward - two things that tend to work in the favor of teams in the tourney. Washington also has an elite scoring forward in Quincy Pondexter and a point guard that pushes tempo well in Isaiah Thomas. Whoever wins this game can beat New Mexico in round two and give West Virginia a run, but picking the winner is a crapshoot to say the least.

Upset special: No. 10 Missouri over No. 7 Clemson
Another weak 10-7 call, but there aren't any other upsets that I think are compelling. Not into Wofford over Wisconsin in the 13-4, already have discussed the 12-5 and 11-6 games, etc. Mizzou coach Mike Anderson's up-tempo, "40 Minutes of Hell" approach has yielded dividends in the past, getting UAB to the Sweet 16 as a nine-seed in 2004 and getting the Tigers to the Elite 8 a year ago. Oliver Purnell, on the other hand, as seen Clemson lose in the first round as a higher seed two years in a row, as a 5 to Villanova in '08 and as a 7 to Michigan last year. I'm feeling a hat trick.

Lead-pipe lock: There will be some fun basketball played in games not involving Wisconsin.
Between the up-tempo teams that I've mentioned early in this thread to the spectacle that Kentucky freshmen John Wall and DeMarcus Cousins create with their soon-to-be-NBA-lottery-picks skill, this will be fun. Kentucky has the most talent in the region, but their youth could hold them back from getting to the Final 4. As for the Badgers, watch at your own risk.

Now to the West Region, which will have its regional finals held in Glendale, Arizona. It will also have some new faces near the top of the regional as well.

Overall theme:
This region will be about putting up or shutting up. The slotting of Connecticut as a top seed was pretty controversial, as the Huskies were the third Big East team to get a No. 1 seed. UConn lost in the first round of the Big East Tournament (albeit in six overtimes) and hasn't won a postseason game - conference tournament or NCAA tournament - since beating Washington in the Sweet 16 three years ago. The Huskies have something to prove.

No. 2 Memphis, who feels that it should have been the top seed, also has a chip on its shoulder. Not only do the Tigers have to deal with the stigma of being from the weak Conference USA, but they also have to deal with their collapse at the free-throw line late in last year's title game that cost them a ring. So if Memphis and UConn make it to the regional final, look out.

Watch out for: Purdue
The No. 5 Boilermakers have been up and down this season, as they were just as capable of losing to Northwestern at home as they were of whipping Big Ten champion Michigan State by 18 points - both things they "accomplished" this year. The volatility that Purdue showed was explained pretty simply - they just haven't been able to stay healthy. Until now.

The Boilermakers were finally at full strength during the Big Ten tournament, with star sophomore Robbie Hummel and defensive sparkplug Chris Kramer finally 100 percent. Not coincidentally, Purdue won the tournament. They have a manageable No. 12 seed in Northern Iowa and can match up physically with No. 4 Washington. They also have the discipline and shooting capability to mess with No. 1 UConn as well.

Stay away from: California
This category could go to a host of teams, No. 13 Mississippi State (the SEC tourney champion - unlikely tourney champions tend to flame out early in the tournament) and No. 4 Washington (struggled a bit down the stretch), or No. 6 Marquette (who I'll address later) but I went with the Golden Bears.

It's tempting to pick a No. 7 seed to win a couple rounds, but Cal is not the one to pick. While the Golden Bears were surprising under first-year coach Mike Montgomery, they faltered a bit down the stretch and are matched up with a No. 10 Maryland team and star guard Greivis Vasquez. Forget about picking Cal to the second round, much less anywhere further.

High risk, high reward: Missouri
I guess its a little weird to have a third seed in this position, but this category has to do with the Tigers' Final Four chances. While UConn and Memphis are getting all of the buzz, Missouri has a chance to sneak through the cracks and make it to Detroit. The Big 12 tourney champions employ a high-intensity, full-court pressing attack reminiscent of Arkansas' "40 Minutes of Hell" under Nolan Richardson.

Missouri also has the best assist-to-turnover ratio in the nation and two talented forward in DeMarre Carroll and Leo Lyons. So where's the risk? The risk is in Missouri's relative inexperience, as it hasn't been to the tourney since 2003, and picking them to the Final Four in a region with two No. 1-seed worthy teams. But a brassy pick here could pay off big time.

Upset special: No. 11 Utah State over No. 6 Marquette
Marquette has the scoring ability to hang with anyone in the nation with seniors Jerel McNeal and Wesley Matthews along with junior Lazar Hayward. But there's one key player missing in senior point guard Dominic James, who broke his foot late in the regular season.

The Eagles, ranked in the top 10 at one point, lost five out of six since James' injury and have been generally off. They had a similar situation two years ago when McNeal went down and fell meekly in the first round to Michigan State. With a Utah State team that has 29 wins staring them in the face, the Eagles look to be in trouble.

Lead-pipe lock: UCLA won't win the region
That might seem like a "No, duh!!" statement, considering that the Bruins aren't even one of the 16 teams in the region, but the West has been UCLA's playground the last three years - as the Bruins have run through on the way to the Final Four each season. But with no UCLA on the docket, teams like Connecticut, Memphis and Missouri can play a little bit more.