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Well, the Throwdown in Motown is hours away and it should be an interesting duo of battles between two favorites and two upstarts, one of which will hold a pretty serious homecourt advantage. But enough of that.

No. 2 Michigan State vs. No. 1 Connecticut
And here is the home team. The Spartans will have much of the crowd at Ford Field in their corner, with East Lansing just over an hour from downtown Detroit. That fan support is very necessary, as Michigan State finds itself playing a UConn team that has been extremely consistent and effective throughout the tournament. Missouri took a lead early in the second half against the Huskies, which is the only time that UConn has really been pressured in this tournament.
The best hope that Sparty has (besides the crowd support) is to get Hasheem Thabeet in foul trouble. I feel like a broken record mentioning that, as I'm pretty sure I have for every UConn game, but without Thabeet's 7-foot-3-inch presence, UConn is different inside and Michigan State has the depth in bigs to exploit it. It'll need to, as the Spartans will have a tough matchup on the perimeter against UConn point guard A.J. Price and freshman shooting guard Kemba Walker. I see MSU hanging tough but the Huskies will be too much.
Pick: UConn

No. 3 Villanova at No. 1 North Carolina
When the Tar Heels won the title four years ago, Villanova was the team that came the closest to knocking them off. In fact, a questionable traveling call on Allan Ray in the final minute was the kill shot to the Wildcats as North Carolina escaped with a 67-66 victory. There's no question that Villanova coach Jay Wright has been replaying that final minute, and that near-miss, in his head all week.
As far as this matchup is concerned, Villanova has the guard play to hang with UNC's Wayne Ellington and Ty Lawson. The Coreys (Stokes and Fisher) and Scottie Reynolds should be a good matchup for UNC. However, the problem teams face with the Tar Heels is that their scoring can come from anywhere. Oklahoma was able to neutralize Tyler Hansbrough's offense in the regional final, only to be bombarded by Ellington, Lawson and Danny Green. The Tar Heels bring offense from all points and its almost impossible to neutralize it all.
Pick: North Carolina

Will we have four No. 1 seeds in the Final Four for the second straight year? The way this tourney has gone, I wouldn't doubt it. But let's see.

West Regional
No. 3 Missouri vs. No. 1 Connecticut
The Tigers opened some eyes Thursday, running and gunning past Memphis while putting up over 100 points in the process. After that performance, which saw Mizzou up by as many as 24 points in the second half, confidence should be high.
But Missouri has never played in a Final Four. And UConn might be playing the most consistent basketball in the tournament to date. Expect Missouri to try to get the Huskies out of their game through the full-court press, but the Tigers will be hard-pressed to contain 7-foot-3 UConn center Hasheem Thabeet. Their best bet would be to get Thabeet in foul trouble and even the odds. Otherwise, the Huskies should win this convincingly.
Pick: Connecticut

East Regional
No. 3 Villanova vs. No. 1 Pittsburgh
Pitt may be the No. 1 seed, but the Wildcats seem to be gathering most of the buzz going into this game. That makes a lot of sense, as Villanova has just wasted Duke and UCLA while the Panthers seem to be ekeing out victories over everyone they play. If you go by how each team is playing, Villanova should be OK.
A couple things could factor in Pittsburgh's favor though. If DeJuan Blair can stay out of foul trouble, he provides a space-eating low-post scoring threat that Villanova has no real counter for. And perhaps like Louisville (which struggled at times in its first two games before destroying Arizona Friday), perhaps the Panthers have a big game in them. They've gotten big individual games from Blair (E. Tenn State), Sam Young (Okla. State) and Levance Fields (Xavier). They need a combo to win this game.
Pick: Villanova

After a relatively successful first round of predictions, I'm going to make a stab at it again. It will be a little more conventional this time around, as I'll be going with straight-up predictions from here on out.

No. 5 Purdue at No. 1 Connecticut
You never know how motivated the Huskies will be from game to game, but if the first two games are any indication, UConn is taking the tournament seriously. Sportsmanship was a bit of an issue in the Chattanooga game, but the Huskies were impressive in trouncing Texas A&M.
Purdue, on the other hand, has won its two games in a variety of ways, subduing Northern Iowa in a half-court, possession game while outlasting Washington in a back-and-forth, fast-paced 76-74 donnybrook. Purdue will give the Huskies a game, but UConn is on a roll now.
Pick: Connecticut.

No. 3 Missouri at No. 2 Memphis
This game should be a fun one. Missouri's full-court press, "40 Minutes of Hell" offense can erupt at any time and the Tigers have a bevy of scoring threats led by forward DeMarre Carroll. Memphis, meanwhile, might have the most athletic team in college basketball.
The key to this game will be Memphis' outside shooting. The Tigers have been torrid from 3-point range in their first two games, with Roburt Sallie going for 10 3-pointers against Cal State Northridge and Doneal Mack leading the rout of Maryland. If that continues, then bye, bye Missouri.
Pick: Memphis