Ryu is already 1-0 with a 0.00 earned-run average after picking up the win last Sunday in Sydney, Australia. Ryu shut out the Arizona Diamondbacks for five innings before a toe injury caused him to come out of the game.
That injury has healed, Mattingly said, and Ryu will oppose Andrew Cashner at Petco Park in the Padres’ Opening Day game.
Clayton Kershaw was originally scheduled to start the game, but a back injury forced him to sit out. Kershaw might begin the season on the disabled list.
Ryu threw a bullpen session prior to Friday’s game and passed that preliminary test. Zack Greinke will pitch the second game of the series Tuesday against Ian Kennedy and Dan Haren will oppose Tyson Ross on Wednesday.
Haren will also start the finale of the Freeway Series on Saturday, a game that’s scheduled to begin just after 6 p.m. at Angel Stadium.